Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

Mascot Distiller version 2.2

All known issues in Mascot Distiller 2.2 have been fixed in later versions.

Updates to version 2.8 are currently free. We recommend all users to download and install this free update.

Change log

2.2.1 (1-Oct-2008)

  • 769: Fixed memory leaks and took steps to reduce memory fragmentation
  • 779: Failing to save type of protein scoring to project file when it has been changed from default
  • 780: Occasional crashes when allow elution time shift is true
  • 781: Failing to re-calculate quantitation table when some format options are changed, e.g. require bold red
  • 793: Crash if encounter MS3 scan without precursor information in Xcalibur file
  • 803: Crash if no peptide matches in the first protein hit can be used for quantitation
  • Add overlay option for TICs in multi-file project
  • Better display of centroided spectra
  • Clearer display when Allow elution time shift is true
  • Clearer messages if quantitation not possible for some reason
  • Crash if outlier method was undefined in quantitation method
  • Creating a multi-file project prompted for developer toolbox licence
  • Misleading error message when Distiller not permitted as client by Mascot security
  • Number of hits in protein tree was AUTO even when fixed number specified in search
  • Quantitation sometimes processed matches with scores below homology threshold when this was the peptide threshold type
  • Support Arg to Pro conversion

2.2.0 (9-Sep-2008)

First release of Quantitation Toolbox

  • 387: Sometimes need separate peak settings for MS and MS/MS.
  • 454: Need some way of merging MUDPIT runs.
  • 497: Implement support for MS3 and greater in time domain processing.
  • 500: Conventional peak detection for reporter ions.
  • 501: Finish implementation of data source verification using hash value.
  • 517: User interface to create eXtracted Ion Chromatograms (XICs).
  • 519: Group mascot results by protein in Explorer.
  • 527: Ensure that regrid conserves relative area.
  • 528: TIC minutes should display mins:secs as well as decimal minutes.
  • 548: Display Expect value for PMF.
  • 588: Peak areas are using bin width as x unit; should be Da.
  • 589: Y axis intensity values displayed are out by factor 10.
  • 608: Minor GUI annoyances.
  • 612: Start sequence tag (11+) is confusing.
  • 615: Need to handle more than 9 variable modifications because of exclusive mods.
  • 625: Updates to distiller_mascot_search_2.xsd schema.
  • 626: Decision logic to locate precursor charge in parent scan not always consistent.
  • 627: Move tree management to App level.
  • 634: Kratos provider not using the non linear calibration functions added at v13.
  • 649: Support Kratos ‘Auto’ experiments.
  • 652: Add new option to client.pl to return compressed result file without ions data.
  • 653: Add stmobjFileModeFlagBinary to stream objects.
  • 655: .rov file type not associated with Distiller on VISTA by default.
  • 656: .rov files not opening on VISTA when double clicked.
  • 664: Add distiller version to mgf file.
  • 668: SDK CHM enum mdroDataSourceFormat_e missing mdroDataSourceFormatAgilentQTof.
  • 670: Distiller fails to select user name in search form.
  • 676: Group identical peptides in protein tree.
  • 678: Unsupported scan type error is returned from Analyst provider if scan is empty.
  • 681: Need to be able to access original peak data for centroided raw files.
  • 683: Unknown scan types can break parent-child connections in the acquisition tree.
  • 685: Rover crashes when trying to add a peak manually.
  • 688: Crash after changing preferences.
  • 690: MDRO properties dialog not sizing correctly for Japan Windows Locale.
  • 691: Changes to Processing Options for Conventional PP.
  • 695: Signal to noise will be incorrect for sparse spectrum.
  • 696: S/N values need a little tweaking…
  • 697: Misc. peak detection improvements.
  • 699: Memoryleak in Voyager provider.
  • 700: Add a property to return summed fit data within range of peaks only.
  • 705: mzData export does not observe MaxPrecision setting.
  • 712: Narrow m/z range baseline subtraction.
  • 713: Need Minimum charge for MS processing in MDRO API.
  • 714: Uncentroid peak width in properties dialog is out by factor of 2.35.
  • 715: Peak list format options should allow user to choose area or S/N.
  • 716: Crash when trying to submit search.
  • 717: Zoom scans from Analyst and Xcalibur providers sometimes have precursor m/z and charge values.
  • 718: Unable to use cached unimod.xml because of Invalid character error.
  • 721: Add version to Distiller user agent string.
  • 722: Accessing schema files on public server instead of local directory.
  • 724: Unable to locate data source after saving project previously stored on another drive.
  • 728: Add /LARGEADDRESSAWARE linker option to MascotDistiller.exe.
  • 735: _DISTILLER_MDRO_VERSION and _DISTILLER_RAWFILE must be off by default.
  • 736: Update XCalibur, MassLynx and Agilent libraries for Distiller 2.2.
  • 737: Need to be able to specify charge state in API call when performing conventional peak picking (SPP).
  • 738: Add licence feature for quantitation toolbox.
  • 744: Add support for Launchpad 2.8 files.
  • 747: Support formats that store both profile and centroided data.
  • 751: Add support for Kratos spliced least squares calibration format files (QIT).
  • 753: Bruker BAF shown as available when it’s not.