Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

Mascot Distiller version 2.4

All known issues in Mascot Distiller 2.4 have been fixed in later versions.

Updates to version 2.8 are currently free. We recommend all users to download and install this free update.

Change log

2.4.3.3 (22-Oct-2012)

  • 11351: Independent multi-file project may fail to consolidate quantitation results from all files

2.4.3.2 (21-Sep-2012)

  • 11303: Crash immediately after choosing 18O quantitation

2.4.3.1 (6-Aug-2012)

  • 11265: Workaround Xcalibur profile spectra returned from MSFileReader that contain decreasing m/z values

2.4.3 (26-Jul-2012)

  • 10851, 10951: In quantitation table, collapse matches to different arrangements of mods that don’t affect the peptide m/z
  • 10887: Update Distiller installer to include MSFileReader 2.2
  • 10904: Second and subsequent MS/MS scans orphaned in Xcalibur Q Exactive data
  • 10908: Allow exclusive quantitation label and variable modifications to target same residue
  • 10927: No quantitation overlay for additional charge state matches
  • 10933: Assert Failure: res < 0 [c:\backedup\chrisa\cvshome\mdro_2_4\mdro\src\engine\signal.h:348]
  • 10934: XICs make no sense for centroid raw data
  • 10945, 10973: Quant XML only lists first search result URL in multi-file project
  • 10955: Improve regridding for compressed profile data with all zero intensity values removed
  • 10956: Axima provider needs updating for files created with LaunchPad 2.9
  • 10967: State of enable control in calibration dialog not being saved or displayed
  • 10972: Precursor m/z taken from Xcalibur Q Exactive file has only 2 decimal places
  • 10977: Baseline in spec window vanishes at high zoom
  • 10993: Open multi-file project and change quant range causes crash
  • 11021: Change labelling in new multi-file project dialog
  • 11028: "Conversion error: Invalid input" when opening Xcalibur RAW file with multiplexing
  • 11033: Keyboard interface to XIC window is broken
  • 11064: Read-only mode should support command line export of quantitation XML
  • 11137: Multifile project with small number of T2D files crashes
  • 11214: Always regrid a profile spectrum returned from the text provider
  • 11219: Fixed crash in Analyst provider for certain types of empty scans
  • 11247: Integration failing occasionally when calculating ratio for replicate
  • 11259: table_matches.xslt displays wrong component name in report for replicate

2.4.2 (18-Oct-2011)

  • 10939: Consistency error when re-open multi-file project if MS/MS peak picking tab was disabled

2.4.1 (6-Oct-2011)

  • 10916: PMF searches fail because charge not set to 1+
  • 10915: Incorrect use of bold in proteins tree for family grouping
  • 10907: Connection problem after specifying incorrect proxy server
  • 10896: Problem with a Windows Mascot Server where the data directory is on different drive from programs
  • 10894: Spectrum window y axis scale tick mark labels sometimes wrong
  • 10892: Crash when loading search form after security session time-out
  • 10889: Installing Distiller 2.4 may downgrade MSFileReader from 2.2 to 2.1
  • 10884: Drop change password button from Mascot security login dialog
  • 10881: Typo in search header text label
  • 10880: Change label for process independently check box to clarify functionality
  • 10879: Replicate tab in format options needs scroll bar
  • 10878: Cannot save MS peak lists from LC-MS/MS dataset
  • 10865: Command line -quantout displays dialogs when processing multi-file project
  • 10863: Crash during quantitation of mzML due to accessing outside scan range
  • 10858: Bruker XMASS / XTOF multi-file-select is broken in 64-bit
  • 10856: Unable to process mzML file containing some empty spectra
  • 10850: IIS integrated authentication broken for multi-file project
  • 10848: Cannot submit very large searches (> 2 GB)
  • 10847: Poor synchronisation between selections in trees and windows
  • 10846: Need to be more intelligent in setting threads
  • 10845: Add context menu option to delete peak list collection
  • 10842: Explorer tree graphics disappear when Distiller loses focus on Win 7
  • 10841: Set default scan selection to centre of XIC when quant fails
  • 10840: Logfile for -batch not always saved to correct location
  • 10837: Drop full path info from chro and scan window title bars
  • 10835: In proteins tree, duplicate Peptide match nodes should be collapsed by default
  • 10833: Remove Processing Options control from new multifile dialog after first project added
  • 10829: Display progress bar when opening non-independent projects
  • 10828: False test for change in threshold value in format options
  • 10826: Avoid displaying node on search tree for duplicate master search
  • 10825: Disable Mascot tag search in multi-file project
  • 10779: Overlay can be inaccurate when baseline subtract set true unless peak widths very narrow
  • 10742: Sequence ladder not displayed correctly for mass values over 10 kDa
  • 9914: Peptide fragment masses stop at 10k in matched fragments table
  • 9876: Quantitation fails for precursor method with 6 or more components
  • 9767: Distiller minidump on crash not working correctly (DBGHELP.DLL not found)

2.4.0 (12-Aug-2011)

  • New feature: 64-bit version
  • New feature: Peak picking and quantitation are now threaded for speed
  • New feature: Install Thermo MSFileReader to support Xcalibur
  • New feature: Install Bruker CompassXtract to support various Bruker formats including maXis
  • New feature: MzML support
  • New feature: Independent processing of multi-file projects to avoid memory problems with very large projects
  • New feature: Automatically fall through to simple integration when fitexy fails
  • New feature: Support Percolator re-scoring
  • New feature: Support Protein Family grouping
  • 10780: Change definition of isPeptideUnique to be unique per family member rather than per family
  • 10769: Bug in Rosners outlier code
  • 10745: ms_mascotresfile doesn’t return INVALID_RESFILE
  • 10698: Use ‘fast’ level of compression by default in project streams
  • 10690: Make providers out of process…
  • 10685: Assertion error ‘Month underflow’ if raw file acquired in January
  • 10684: CreateSpectrum (and related) speed improvement
  • 10670: Inconsistent calculation of m/z values when uncentroiding a spectrum
  • 10669: Peak detection performance improvements
  • 10666: Use cache files to speed project loading
  • 10639: Add zip64 support to zip storage library
  • 10627: On Windows, NTFS, cache files get re-created when going to/from Summer Time (Daylight savings)
  • 10536: IgnoreIonsScoreBelow is converted to a score and rounded to an integer internally
  • 9917: IgnoreIonsScore is double
  • 9915: Display SD in italics if distribution NN
  • 9909: Distiller truncates rather than rounds neutral losses so MetOx comes out at 63
  • 9908: Distiller crashes if unknown scan types in the tree
  • 9906: Search result import from command line should be just that
  • 9901: Add Count/Size information to streams when possible
  • 9897: Support Percolator
  • 9896: Display FDR and search parameters in Explorer tree
  • 9895: Support Protein Family grouping
  • 9892: Process and Search menu item
  • 9889: Need to restart Distiller to get new Quantitation method
  • 9888: XRawFile sometimes returns an incorrect number of precursors
  • 9887: Hard to explain numbers for simple ratio
  • 9886: ‘Y Scale Up’ in View menu is actually an error message string
  • 9885: Modification Carbamidomethyl%20(C) is not in the current list of modifications
  • 9884: After upgrading to Distiller 2.3, Wizard crashes when opening a data source
  • 9883: Name and email not saved in search form
  • 9882: No proteins tab for PMF
  • 9881: Unable to retrieve scan information from the data source. (1)
  • 9880: Minimise reprocessing when quantitation options are changed
  • 9878: Clicking on a peptide in quantitation tab causes a crash
  • 9874: Quantitation result XML includes leading whitespace for N & C terminal modifications
  • 9872: Regridding in summed scans is not correct
  • 9870: Std Err threshold should reject matches where fit fails with result 999
  • 9869: Error loading quantitation results but nothing in log
  • 9868: Unable to retrieve scan information from the data source (Invalid Retention Time)
  • 9867: Cannot open project created in 2.3.1
  • 9864: Display error tolerant search matches
  • 9853: N-term modifications in quant table prefixed by (c-term)
  • 9850: Distiller crashes when quantitating protein 74 in this ion trap file
  • 9848: Need mzML provider
  • 9843: Mysterious Quantitation is cancelled. Normalisation method is reset to ‘none’
  • 9842: Need to support Waters XEVO-TQMS data
  • 9841: Isotope separation for satellite peaks due to under-enrichment incorrect?
  • 9827: Distiller Workstation is missing functions provided in free viewer
  • 9825: Add command line argument to export a quantitation report
  • 9813: command line could have option to export and save quant XML file
  • 9805: Disable Denovo when Always Uncentroid = false (MS/MS)
  • 9690: Export de novo solution as CSV
  • 9670: Drop Agilent Analyst provider
  • 9659: Explorer tree, Peak tab, PMF should show which are the calibration scans.
  • 9653: Message that Mascot server is off-line when you choose search
  • 9621: Wait flag for CreatePeakLists
  • 9591: Improve performance of peak processing, esp. on multi-core CPUs
  • 9465: Change Search priority from Distiller
  • 9442: Processing huge Masslynx file, containing just MS data, feels on the edge
  • 9309: Distiller GUI can hang when using log window